A Definitive Guide to Pathogenesis, Risk Stratification, and Advanced Management Strategies

By Myron N. Carnes, MD, FACP; Sheila H. Renfro, MD, PhD; and Gary P. Liriano, MD, MPH

Multiple myeloma remains a complex and evolving hematologic malignancy, necessitating a deep understanding of its pathogenesis, diagnostic intricacies, and rapidly advancing treatment landscape. This authoritative guide provides a structured, evidence-based approach, offering clinicians, researchers, and healthcare professionals a comprehensive resource for navigating the latest advancements in disease assessment, risk stratification, and therapeutic innovations.

✔ Pathogenesis and Molecular Mechanisms - Gain insights into the underlying biology of multiple myeloma, including the role of genetic mutations, clonal evolution, and tumor microenvironment interactions that drive disease progression.

✔ Advanced Diagnostic Techniques - Explore cutting-edge strategies for early and accurate diagnosis, from serum protein electrophoresis and immunofixation to next-generation sequencing, cytogenetic profiling, and advanced imaging modalities such as PET-CT and whole-body MRI.

✔ Risk Stratification and Prognostic Indicators - Learn how to assess disease severity using refined scoring systems, including the Revised International Staging System (R-ISS), cytogenetic risk classifications, and minimal residual disease (MRD) assessment to guide individualized treatment plans.

✔ State-of-the-Art Treatment Approaches - Examine the latest standards of care, including proteasome inhibitors, immunomodulatory agents, monoclonal antibodies, and combination regimens, along with personalized therapy considerations based on patient-specific factors.

✔ Emerging Therapies and Future Directions - Stay informed on groundbreaking advancements, including CAR-T cell therapy, bispecific antibodies, next-generation proteasome inhibitors, and novel immunotherapeutic strategies reshaping the treatment paradigm.

✔ Stem Cell Transplantation and Cellular Therapy - Understand the role of autologous and allogeneic stem cell transplantation, conditioning regimens, and post-transplant maintenance strategies to optimize long-term outcomes.

✔ Supportive Care and Long-Term Management - Address critical aspects of patient care, including bone health management, renal protection, infection prevention, thromboembolic risk mitigation, and quality-of-life considerations for individuals living with multiple myeloma.

This definitive reference serves as an essential resource for oncologists, hematologists, fellows, advanced practitioners, and medical students seeking a deeper understanding of multiple myeloma. With a focus on translating scientific advancements into clinical practice, this guide equips healthcare professionals with the knowledge needed to navigate complex treatment decisions and optimize patient outcomes in this rapidly evolving field.