This book describes the lives of these remarkable scientists, and suggests that they had several things in common. First, although they were well known for their original scientific findings, they were equally recognized for the brilliant students they gathered. Second, Müller and Meynert, who had begun their careers with creatively disruptive ideas, were perceived as having later become entrenched in their original findings, with difficulty moving forward. The third similarity in these histories is that the relationships of Müller and Meynert with their students were often complex, in some cases involving resentment and alienation. This was most notable in the stories of Müller and his trainee Emil du Bois-Reymond, as well as of Meynert and the newly minted physician in his clinic, Sigmund Freud.

This book examines these three themes, and explores, as well, the vulnerabilities of these mentors; Müller, for instance, made his many discoveries while suffering from depressive episodes, and ultimately died by his own hand. Meynert, on this deathbed, apparently confessed to having suffered from what was then known as male hysteria.

The author, a psychiatrist with over 40 years of experience, describes here how these two scientists achieved so much while dealing with both internal vulnerabilities and complex relationships with their students. He concludes that many advances have been made, not simply from the imparting of wisdom by teachers to students of the next generation, but rather from their very human, and often conflictual, interactions.