Estrogen Dominance Syndrome (EDS) unveils the intricate and far-reaching consequences of a hormonal imbalance where estrogen overshadows progesterone and testosterone, disrupting the body's delicate equilibrium. This comprehensive book explores how this relative excess of estrogen-a vital hormone influencing reproductive health, metabolism, and even mood-can trigger a cascade of symptoms, from irregular menstrual cycles and infertility in women to reduced libido and gynecomastia in men, while also contributing to metabolic disorders, cardiovascular risks, and mood disturbances. It further examines emerging research on EDS's potential role in gender dysphoria, suggesting that hormonal imbalances may influence experiences of gender identity, adding another layer to its complexity. Delving into the hypothalamic-pituitary-gonadal axis and the interplay with stress hormones like cortisol, this work highlights the multifactorial nature of EDS, its elusive diagnosis due to the lack of a singular test, and its profound impact on quality of life and healthcare systems. Through a holistic lens, it offers insights into prevalence, symptoms, and innovative management strategies, urging greater awareness and research into this underrecognized yet pervasive condition.