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Atorvastatin Self-Emulsified Tablets Formulation and Evaluation
Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble medications. When SEDDS are added to an aqueous phase and gently mixed, fine oil-in-water emulsions form. SEDDS come in soft or hard gelatin capsules for oral administration and form fine, stable oil-in-water emulsions. SEDDS are primarily manufactured as liquid formulations, which have poor stability and mobility, low drug loading, a limited number of dosage form options, irreversible drug/excipient precipitation, and a high proportion (30-60%) of surfactants that might irritate the gastrointestinal system. Solid-SEDDS has been studied to avoid the problems of liquid SEDDS. The adsorption of liquid self-micro-emulsified formulations on solid carriers is one of the best ways to create free-flowing powders for compression into tablet dosage form (SMET).
Book Details
- Publisher: LAP Lambert Academic Publishing
- Publish Date: Dec 29th, 2022
- Pages: 76
- Language: English
- Edition: undefined - undefined
- Dimensions: 9.00in - 6.00in - 0.18in - 0.27lb
- EAN: 9786205528082
- Categories: • Pharmacology