For Tempe Brennan, the discovery of a young girl's skeleton in Acadia, Canada, is more than just another case. Evangeline, Tempe's childhood best friend, was also from Acadia. Named for the character in the Longfellow poem, Evangeline was the most exotic person in Tempe's eight-year-old world. When Evangeline disappeared, Tempe was warned not to search for her, that the girl was "dangerous."

Thirty years later, flooded with memories, Tempe cannot help wondering if this skeleton could be the friend she had lost so many years ago. And what is the meaning of the strange skeletal lesions found on the bones of the young girl?

Meanwhile, Tempe's beau, Ryan, investigates a series of cold cases. Two girls dead. Three missing. Could the New Brunswick skeleton be part of the pattern? As Tempe draws on the latest advances in forensic anthropology to penetrate the past, Ryan hunts down a serial predator.