High Quality Content by WIKIPEDIA articles! Drusilla is a fictional character created by Joss Whedon and David Greenwalt for the American television series, Buffy the Vampire Slayer and Angel. The character is portrayed by American actress Juliet Landau. Drusilla is introduced alongside her lover Spike (James Marsters) in the second season of Buffy the Vampire Slayer to serve as new antagonists to the series' heroine, Vampire Slayer Buffy Summers (Sarah Michelle Gellar). In contrast to the series' previous central villain, the ancient and ceremonious Master (Mark Metcalf), Spike and Dru were introduced as more unconventional but equally dangerous pair of Vampires.