Brown interviews enthusiasts from twelve states--Alabama, Arkansas, Florida, Georgia, Kentucky, Louisiana, Mississippi, North Carolina, South Carolina, Tennessee, Texas, and Virginia. Ghost Hunters of the South takes the reader along on exciting and fearful investigations of places such as the Myrtles, St. Francis Inn, Chickamauga Battlefield, Bob Mackey's Music World, Old Talbott Tavern, North Carolina State Capitol, Granberry Opera House, and 17Hundred90 Inn and Restaurant.

Brown participates in some of the investigations to gain a full and objective understanding of teachers, doctors, accountants, housewives, and law enforcement personnel, who devote much of their free time to a quest that many outsiders view with skepticism if not scorn. In fascinating, frightening, and sometimes humorous accounts, Brown highlights the determination of these individuals to answer the question: "What happens to the soul after death?"