On his way back to the U.S. to meet up with his fellow Saints, there's a lot weighing on Sebastian's mind. Though the stakes are already high with the fate of the human race, plus the abduction of his ghost brother, and his new girlfriend, a complicated situation nevertheless gets more complex. The Saint traitor abruptly reveals himself, and along with the goth hitman, Lucian, who has similar mind-reading abilities as Sebastian, they attempt to capture Sebastian and deliver him to Ashe.

But Sebastian is no longer an outlaw, and has help from his Saint confederates. The tables quickly turn, using Ashe's own strategy against him to allow Sebastian to penetrate his hidden base. The ploy comes with a brutal price as Sebastian is trapped alone, bound, and beaten, yet all will be worth it if the Saints can track him in time.

Until they do, Sebastian and Marcellus are at Ashe's mercy, and must play unwilling integral parts in a bizarre scheme that incorporates a mysterious, supernatural gate to an ancient, alternate version of Earth. Once Ashe's mystery machines are turned on, the dimensional energy from the alternate Earth will be pulled through the gate, washing over our world to wipe it clean of human beings.

It's a war greater than anything The Saints are prepared to fight, and is waged on three fronts. Sebastian and Benedict face off against Ashe, Lucian, and a host of croco-wolves in a modern-day Arizona cavern while Marcellus and Kasey are stuck in ancient Egypt trying to stop Troy the Dragon-boy, all while the remainder of The Saints battle a cornucopia of Ashe's fanged monstrosities and well-armed mercenaries in the Grand Canyon desert.

Once the doomsday machines turn on, and the fatal energy flows through the gate, every minute spent fighting Ashe's men is a minute closer to a cataclysmic fate that the world cannot reverse.