Private Detective Tree Callister thinks he's dying. He could be right. Humphrey Bogart doesn't give him much hope. A floppy-eared hound dog named Clinton insists on talking to him. Meanwhile, a mysterious list sends Tree and his wife Freddie from Sanibel Island to Savannah, Georgia to Washington, D.C. Along the way they encounter a demented ex-football player, a crooked small-town sheriff who likes to use his Taser, and two women in love married to the same man. A plane explodes. A dead body shows up. All hell breaks loose. And Tree discovers it's hard to worry about dying when all sorts of people are trying to kill you.