Rain is a young woman under the influence of a charismatic drifter named Wolf and his other "wife," Winter. Through months of wandering homeless through the cities, small towns, and landscape of Appalachia, the trio have grown into a kind of desperate family, a family driven by exploitation and abuse. A family that Rain must escape.

When she meets Stratton Bryant, a widower living alone in an old east Tennessee farmhouse, Rain is given the chance to see a bigger world and find herself a place within it. But Wolf will not let her part easily. When he demands loyalty and obedience, the only way out is through an episode of violence that will leave everyone involved permanently damaged.

A harrowing story of choice and sacrifice, Charles Dodd White's In the House of Wilderness is a novel about the modern South and how we fight through hardship and grief to find a way home.