Ethel Gathers, the proud wife of an American Officer, is living in Occupied Germany in the 1950s. After discovering a local orphanage filled with the abandoned mixed-race children of German women and Black American GI's, Ethel feels compelled to help find these children homes.

Philadelphia born Ozzie Phillips volunteers for the recently desegregated army in 1948, eager to make his mark in the world. While serving in Manheim, Germany, he meets a local woman, Jelka, and the two embark on a relationship that will impact their lives forever.

In 1965 Maryland, Sophia Clark is given an opportunity to attend a prestigious all white boarding school and escape her heartless parents. While at the school, she discovers a secret that upends her world and sends her on a quest to unravel her own identity.

Toggling between the lives of these three individuals, Keeper of Lost Children explores how one woman's vision will change the course of countless lives, and demonstrates that love in its myriad of forms--familial, parental, and forbidden, even love of self--can be transcendent.