The book begins with Anna J. Cooper's philosophy on race literature as one method for social advancement. From there, author Coretta M. Pittman discusses women from the Woman's and New Negro Eras, including but not limited to Angelina Weld Grimké, Gertrude "Ma" Rainey, and Zora Neale Hurston. The volume closes with an exploration of Victoria Spivey's blues philosophy. The women examined in this book employ forms of transformational, transactional, or specular literacy to challenge systems of racial oppression.

However, Literacy in a Long Blues Note argues against prevalent myths that a singular vision for racial uplift dominated the public sphere in the latter decade of the nineteenth century and the early decades of the twentieth century. Instead, by including Black women from various social classes and ideological positions, Pittman reveals alternative visions. Contrary to more moderate predecessors of the Woman's Era and contemporaries in the New Negro Era, classic blues singers like Mamie Smith advanced new solutions against racism. Early twentieth-century writer Angelina Weld Grimké criticized traditional methods for racial advancement as Jim Crow laws tightened restrictions against Black progress. Ultimately, the volume details the agency and literacy practices of these influential women.