It's 1999, and best friends Sal and Charo are striving to hold on to their dreams in a New York determined to grind them down. Sal is a book-loving science nerd trying to grow beyond his dead-end job in a new city, but he's held back by tragic memories from his past in Santo Domingo. Free-spirited Charo is surprised to find herself a mother at twenty-five, partnered with a controlling man, working at the same supermarket for years, her world shrunk to the very domesticity she thought she'd escaped in her old country. When Sal finds love at a gay club one night, both his and Charo's worlds unexpectedly open up to a vibrant social circle that pushes them to reckon with what they owe to their own selves, pasts, futures, and, always, each other.

Loca follows one daring year in the lives of young people living at the edge of their own patience and desires. With expansive grace, it reveals both the grueling conditions that force people to migrate and the possibility of friendship as home when family, nations, and identity groups fall short.