- Definitive new edition supervised by creator Shirow Masamune
- In the original, right-to-left format with Japanese sound effects for the first time!
- Released simultaneously with deluxe editions of The Ghost in the Shell 1 and 1.5

The long-awaited sequel to Shirow Masamune's groundbreaking The Ghost in the Shell, and one of the most highly anticipated graphic novel events in many years, Man-Machine Interface is Shirow's most ambitious and complex story yet, with deep forays into philosophy and the meaning of artificial life, intelligence, and existence.