"This final installment of the Dewey Decimal trilogy capably stands alone as a quirky, sparkly read that will embiggen your cerebellum." --Library Journal

"Larson treats the English language as a sort of toy to play with and use for experimentation; language is not just used to tell the story, in other words, but is a part of the story, an extension of its narrator, Dewey Decimal, one of the more offbeat characters in fiction. A fitting conclusion to a unique and memorable trilogy. --Booklist

The Immune System is the explosive final installment in the Dewey Decimal trilogy. Picking up months after the events of The Nervous System, Dewey finds himself running dirty operations for the crooked Senator Howard. When Dewey is tasked with disrupting unrest from a growing group of outcast civilians, and simultaneously given the assignment of protecting a pair of Saudi royals, he is forced to look within and make some impossible choices. Ultimately, this puts him at odds with his benefactor and the powers that be.

In the course of the novel, we learn the true nature of the 2/14 cataclysm that decimated New York City, and by the end of it, Dewey must choose whether or not to face his own past. He must also decide if he is to be part of the elite control system, or if he's willing to commit himself to the unknown, without the protections he enjoys in the good favor of the landlords of the new New Order.