Grace Reinhart Sachs is living her best life. Devoted to her husband, a pediatric oncologist at a major cancer hospital, their young son Henry, and the patients she sees in her therapy practice, her days are full of familiar things. Grace is also the author of a book You Should Have Known, in which she cautions women to really hear what men are trying to tell them.

But weeks before the book is published a chasm opens in her own life: a violent death, a missing husband, and, in the place of a man Grace thought she knew, only an ongoing chain of terrible revelations, leading her to dismantle her life in order to create a new one, lest she allow these disasters to destroy her.