The small rural town of Manasseh has not reported a single death from the plague - or a single death at all - in over twenty years. Tasking Christian with traveling to Manasseh and deducing the cause of the apparent stout health of its residents, Father Stemmons appoints the Scot mercenary Cotton Smith-Patton to act as his ward's bodyguard. Together, the two encounter all manner of strange and diabolical characters before their journey's horrific end.

In the midst of an evil as old as mankind, Christian unexpectedly encounters the seductive beauty, Cassandra, who nightly stalks his dreams. Almost too late he discovers the unholy secret that lies beyond the passion in her eyes, and in his tortured soul comes to realize that she is among those-To Be Damned.