Doro knows no higher authority than himself. An ancient spirit with boundless powers, he possesses humans, killing without remorse as he jumps from body to body to sustain his own life. With a lonely eternity ahead of him, Doro breeds supernaturally gifted humans into empires that obey his every desire. He fears no one -- until he meets Anyanwu.

Anyanwu is an entity like Doro and yet different. She can heal with a bite and transform her own body, mending injuries and reversing aging. She uses her powers to cure her neighbors and birth entire tribes, surrounding herself with kindred who both fear and respect her. No one poses a true threat to Anyanwu -- until she meets Doro.

The moment Doro meets Anyanwu, he covets her; and from the villages of 17th-century Nigeria to 19th-century United States, their courtship becomes a power struggle that echoes through generations, irrevocably changing what it means to be human.